Article

Dynamic changes in tRNA modifications and abundance during T-cell activation

2020-03-15

Abstract excerpt

The tRNA pool determines the efficiency, throughput, and accuracy of translation. Previous studies have identified dynamic changes in the tRNA supply and mRNA demand during cancerous proliferation. Yet, dynamic changes may occur also during physiologically normal proliferation, and these are less characterized. We examined the tRNA and mRNA pools of T-cells during their vigorous proliferation and differentiation u...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: aca497db-1ec4-5f69-bdb7-3fe98ed5ce6a
DOI: 10.1101/2020.03.14.991901

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Dynamic changes in tRNA modifications and abundance during T-cell activationDOI 10.1101/2020.03.14.991901Read

Codon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responsesSemantic proximity Read

SARS-CoV-2 Displays a Suboptimal Codon Usage Bias for Efficient Translation in Human Cells Diverted by Hijacking the tRNA EpitranscriptomeSemantic proximity Read

Essentiality and dynamic expression of the human tRNA pool during viral infectionSemantic proximity Read

Translational efficiency across healthy and tumor tissues is proliferation-relatedSemantic proximity Read

Emerging roles of tRNA in adaptive translation, signalling dynamics and disease.Semantic proximity Read

Host tRNA modifications drive efficient translation of influenza A virus genome and impact host antiviral stress responsesSemantic proximity Read

A proliferation associated tRNA regulatory nexus on human chromosome 6 plays a central role in cell state-dependent gene expressionSemantic proximity Read

tRNA modifications: greasing the wheels of translation and beyondSemantic proximity Read

Charging the code — tRNA modification complexesSemantic proximity Read

Growth-dependent tRNA Reprogramming and Codon Bias Link Translation to Metabolic State in <i>Enterococcus faecalis</i>Semantic proximity Read

Transfer RNA modification and infection – Implications for pathogenicity and host responsesSemantic proximity Read

Dengue virus exploits the host tRNA epitranscriptome to promote viral replicationSemantic proximity Read