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Biological Significance and Therapeutic Promise of Programmed Ribosomal Frameshifting

3 Feb 2025

Abstract excerpt

Programmed Ribosomal Frameshifting (PRF) is a mechanism that alters the mRNA reading frame during translation, resulting in the production of out-of-frame proteins. PRF plays crucial roles in maintaining cellular homeostasis and contributes significantly to disease pathogenesis, particularly in viral infections. Notably, PRF can induce immune responses in the SARS-CoV-2 mRNA vaccine, further extending its...

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PMID: 39941062
DOI: 10.3390/ijms26031294

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