Article
Conditional Switch between Frameshifting Regimes upon Translation of dnaX mRNA.
Molecular cell - 18 May 2017
Caliskan Neva, Wohlgemuth Ingo, Korniy Natalia, Pearson Michael, Peske Frank, Rodnina Marina V
Abstract excerpt
Ribosome frameshifting during translation of bacterial dnaX can proceed via different routes, generating a variety of distinct polypeptides. Using kinetic experiments, we show that -1 frameshifting predominantly occurs during translocation of two tRNAs bound to the slippery sequence codons. This pathway depends on a stem-loop mRNA structure downstream of the slippery sequence and operates when aminoacyl-tRNAs are...
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