Article

Fine mapping spatiotemporal mechanisms of genetic variants underlying cardiac traits and disease

2021-09-02

Abstract excerpt

The causal variants and genes underlying thousands of cardiac GWAS signals have yet to be identified. Here, we leveraged spatiotemporal information on 966 RNA-seq cardiac samples and performed an expression quantitative trait locus (eQTL) analysis detecting eQTLs considering both eGenes and eIsoforms. We identified 2,578 eQTLs associated with a specific developmental stage-, tissue- and/or cell type. Colocalizatio...

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Literature Corpus work: da8a2586-e191-5911-b454-4f1c0424dd58
DOI: 10.1101/2021.09.01.458619

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