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Article

Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension.

American journal of human genetics - 5 Oct 2023

van Duijvenboden Stefan, Ramírez Julia, Young William J, Olczak Kaya J, Ahmed Farah, Alhammadi Mohammed J A Y, Bell Christopher G, Morris Andrew P, Munroe Patricia B

Abstract excerpt

Genome-wide association studies of blood pressure (BP) have identified >1,000 loci, but the effector genes and biological pathways at these loci are mostly unknown. Using published association summary statistics, we conducted annotation-informed fine-mapping incorporating tissue-specific chromatin segmentation and colocalization to identify causal variants and candidate effector genes for systolic BP, diastolic...

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Share to Genetic Predisposition to Disease
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37683633
DOI: 10.1016/j.ajhg.2023.08.009
PMCID: PMC10577090

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