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Article

Multi-ancestry genetic analysis of gene regulation in coronary arteries prioritizes disease risk loci.

Cell genomics - 10 Jan 2024

Hodonsky Chani J, Turner Adam W, Khan Mohammad Daud, Barrientos Nelson B, Methorst Ruben, Ma Lijiang, Lopez Nicolas G, Mosquera Jose Verdezoto, Auguste Gaëlle, Farber Emily, Ma Wei Feng, Wong Doris, Onengut-Gumuscu Suna, Kavousi Maryam, Peyser Patricia A, van der Laan Sander W, Leeper Nicholas J, Kovacic Jason C, Björkegren Johan L M, Miller Clint L

Abstract excerpt

Genome-wide association studies (GWASs) have identified hundreds of risk loci for coronary artery disease (CAD). However, non-European populations are underrepresented in GWASs, and the causal gene-regulatory mechanisms of these risk loci during atherosclerosis remain unclear. We incorporated local ancestry and haplotypes to identify quantitative trait loci for expression (eQTLs) and splicing (sQTLs) in coronary...

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Identifiers

PMID: 38190101
DOI: 10.1016/j.xgen.2023.100465
PMCID: PMC10794848

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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