Article
Synthesis of 53 tissue and cell line expression QTL datasets reveals master eQTLs.
BMC genomics - 27 Jun 2014
Zhang Xiaoling, Gierman Hinco J, Levy Daniel, Plump Andrew, Dobrin Radu, Goring Harald H H, Curran Joanne E, Johnson Matthew P, Blangero John, Kim Stuart K, O'Donnell Christopher J, Emilsson Valur, Johnson Andrew D
Abstract excerpt
BACKGROUND: Gene expression genetic studies in human tissues and cells identify cis- and trans-acting expression quantitative trait loci (eQTLs). These eQTLs provide insights into regulatory mechanisms underlying disease risk. However, few studies systematically characterized eQTL results across cell and tissues types. We synthesized eQTL results from >50 datasets, including new primary data from human brain,...
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