Article

Fine-mapping causal tissues and genes at disease-associated loci

2023-11-01

Abstract excerpt

Heritable diseases often manifest in a highly tissue-specific manner, with different disease loci mediated by genes in distinct tissues or cell types. We propose Tissue-Gene Fine-Mapping (TGFM), a fine-mapping method that infers the posterior probability (PIP) for each gene-tissue pair to mediate a disease locus by analyzing GWAS summary statistics (and in-sample LD) and leveraging eQTL data from diverse tissues t...

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Literature Corpus work: cabf11d8-39d9-5795-ad45-2f57cc6747c9
DOI: 10.1101/2023.11.01.23297909

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