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Article

Fine mapping of candidate effector genes for heart rate.

Human genetics - 1 Oct 2024

Ramírez Julia, van Duijvenboden Stefan, Young William J, Chen Yutang, Usman Tania, Orini Michele, Lambiase Pier D, Tinker Andrew, Bell Christopher G, Morris Andrew P, Munroe Patricia B

Abstract excerpt

An elevated resting heart rate (RHR) is associated with increased cardiovascular mortality. Genome-wide association studies (GWAS) have identified > 350 loci. Uniquely, in this study we applied genetic fine-mapping leveraging tissue specific chromatin segmentation and colocalization analyses to identify causal variants and candidate effector genes for RHR. We used RHR GWAS summary statistics from 388,237...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38969939
DOI: 10.1007/s00439-024-02684-z
PMCID: PMC11485034

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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