Article

Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension

2023-01-27

Abstract excerpt

Genome-wide association studies of blood pressure (BP) have identified >1000 loci but the effector genes and biological pathways at these loci are mostly unknown. Using published meta-analysis summary statistics, we conducted annotation-informed fine-mapping incorporating tissue-specific chromatin segmentation to identify causal variants and candidate effector genes for systolic BP, diastolic BP, and pulse pressur...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0feaa449-ceed-5d49-9bfa-22398e0cd4ee
DOI: 10.1101/2023.01.26.525702

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertensionDOI 10.1101/2023.01.26.525702Read

Integration of genetic fine-mapping and multi-omics data reveals candidate effector genes for hypertension.Semantic proximity Read

Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.Semantic proximity Read

Identification of the molecular components of enhancer-mediated gene expression variation in multiple tissues regulating blood pressureSemantic proximity Read

Fine mapping of candidate effector genes for heart rate.Semantic proximity Read

Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressureSemantic proximity Read

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.Semantic proximity Read

Novel and Known Genetic Players in Hypertension: From Gene Expression to Striking InsightsSemantic proximity Read

Identification of the Molecular Components of Enhancer-Mediated Gene Expression Variation in Multiple Tissues Regulating Blood Pressure.Semantic proximity Read

Association analyses of predicted loss-of-function variants prioritized 15 genes as blood pressure regulatorsSemantic proximity Read

Loci influencing blood pressure identified using a cardiovascular gene-centric array.Semantic proximity Read

Association Analyses of Predicted Loss-of-Function Variants Prioritized 15 Genes as Blood Pressure Regulators.Semantic proximity Read

Tissue-specific and tissue-agnostic effects of genome sequence variation modulating blood pressure.Semantic proximity Read