Article

Remodeling of human colon plasma cell repertoire in ulcerative colitis

2022-02-14

Abstract excerpt

Plasma cells (PCs) constitute a significant fraction of cells in colonic mucosa and contribute to inflammatory lymphocytic infiltrates in ulcerative colitis (UC). While gut PCs secrete 3-5 g of immunoglobulins daily, including IgA antibodies that target colitogenic bacteria, their role in UC is not known. Here, we combined B cell sorting with single-cell VDJ- and RNA-seq and monoclonal antibody (mAb) testing to ch...

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Literature Corpus work: da465d83-32dc-5da0-96f3-76b32568aca8
DOI: 10.1101/2022.02.14.480403

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