Article

Integration of single-cell transcriptome and genetic profiles reveals critical cell types and genes in inflammatory bowel disease

2025-12-09

Abstract excerpt

The progression of inflammatory bowel disease (IBD), grouped into Crohn’s disease (CD) and ulcerative colitis (UC), involves multiple cell types and genes, but the identification of critical cell types and genes that contribute to intestinal inflammation remains challenging. By integrating human intestinal single-cell transcriptomic data from approximately 200 donors, we revealed the stromal cell-derived network i...

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Literature Corpus work: 0223eb9f-9514-5ec9-9c14-a7a801e38763
DOI: 10.64898/2025.12.06.692714

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