Article

High throughput profiling of the B cell repertoire identifies systematic changes in the repertoire of individuals with Crohn’s disease

2025-09-04

Abstract excerpt

The B cell repertoire contains the recombined DNA sequences that encodes the entire antibody repertoire of an individual. The repertoire is made from three antigenic binding chains, namely the immunoglobulin heavy chain (IGH) and two immunoglobulin light chains, κ (IGK) and λ (IGL). Compared to the T cell repertoire, the B cell repertoire is understudied in inflammatory bowel diseases (IBD) even though different a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d186d79f-039a-5f1b-93da-71a1d22eeb99
DOI: 10.1101/2025.09.01.673486

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

High throughput profiling of the B cell repertoire identifies systematic changes in the repertoire of individuals with Crohn’s diseaseDOI 10.1101/2025.09.01.673486Read

Simultaneous Profiling of the Blood and Gut T and B Cell Repertoires in Crohn’s Disease and Symptomatic Controls Illustrates Tissue-specific Alterations in the Immune Repertoire of Crohn’s Disease PatientsSemantic proximity Read

Antigen-driven expansion of public clonal T cell populations in inflammatory bowel diseasesSemantic proximity Read

Multi-centered T cell repertoire profiling identifies novel alterations in the immune repertoire of individuals with inflammatory bowel disease and validates previous findingsSemantic proximity Read

Antigen-driven expansion of public clonal T-cell populations in inflammatory bowel diseasesSemantic proximity Read

Remodeling of human colon plasma cell repertoire in ulcerative colitisSemantic proximity Read

Analyzing the T cell receptor repertoire of 2,804 individuals with inflammatory bowel disease identifies public T cell responses involved in the pathogenesisSemantic proximity Read

Longitudinal TCR repertoires in ulcerative colitis patients show features distinguishing disease statesSemantic proximity Read

In-Depth Assessment of Within-Individual and Inter-Individual Variation in the B Cell Receptor RepertoireSemantic proximity Read

Longitudinal T cell repertoire analysis reveals dynamic clonal T cell populations in Ulcerative ColitisSemantic proximity Read

Assessing human B cell repertoire diversity and convergence.Semantic proximity Read

Antigen-level resolution of commensal-specific B cell responses enabled by phage-display screening and B cell tetramersSemantic proximity Read

Antibody repertoire analysis in polygenic autoimmune diseasesSemantic proximity Read