Article

Longitudinal TCR repertoires in ulcerative colitis patients show features distinguishing disease states

2025-08-01

Abstract excerpt

<h4>ABSTRACT AND KEY WORDS</h4> <h4>Background</h4> Ulcerative colitis (UC) affects an estimated 10 million people worldwide. The exact etiology of the disease is unknown, but T cell dysregulation and aberrant activation is associated with UC—prompting research into T cell receptor (TCR) repertoires in UC patients. However, few studies have compared UC patients’ TCR repertoires in flare (inflamed) and remission...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 60cd9ab2-de75-5f90-9fb4-f456daf30721
DOI: 10.1101/2025.07.31.667918

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Longitudinal TCR repertoires in ulcerative colitis patients show features distinguishing disease statesDOI 10.1101/2025.07.31.667918Read

Longitudinal T cell repertoire analysis reveals dynamic clonal T cell populations in Ulcerative ColitisSemantic proximity Read

Multi-centered T cell repertoire profiling identifies novel alterations in the immune repertoire of individuals with inflammatory bowel disease and validates previous findingsSemantic proximity Read

Antigen-driven expansion of public clonal T cell populations in inflammatory bowel diseasesSemantic proximity Read

Simultaneous Profiling of the Blood and Gut T and B Cell Repertoires in Crohn’s Disease and Symptomatic Controls Illustrates Tissue-specific Alterations in the Immune Repertoire of Crohn’s Disease PatientsSemantic proximity Read

High throughput profiling of the B cell repertoire identifies systematic changes in the repertoire of individuals with Crohn’s diseaseSemantic proximity Read

Colonic mucosal associated invariant T cells in Crohn’s disease have a diverse and non-public T cell receptor beta chain repertoireSemantic proximity Read

Antigen-driven expansion of public clonal T-cell populations in inflammatory bowel diseasesSemantic proximity Read

Shared CD4+ T cell receptor specificity groups in Crohn's disease and ulcerative colitis.Semantic proximity Read

Analyzing the T cell receptor repertoire of 2,804 individuals with inflammatory bowel disease identifies public T cell responses involved in the pathogenesisSemantic proximity Read

Remodeling of human colon plasma cell repertoire in ulcerative colitisSemantic proximity Read

Bacterial superantigens and T cell receptor beta-chain-bearing T cells in the immunopathogenesis of ulcerative colitis.Semantic proximity Read

Evaluation of colorectal cancer in ulcerative colitis reveals key immune factors during its malignant transformationSemantic proximity Read