Article
IgA Plasma Cells Are Long-Lived Residents of Gut and Bone Marrow That Express Isotype- and Tissue-Specific Gene Expression Patterns.
Frontiers in immunology - 1 Jan 2021
Wilmore Joel R, Gaudette Brian T, Gómez Atria Daniela, Rosenthal Rebecca L, Reiser Sarah Kim, Meng Wenzhao, Rosenfeld Aaron M, Luning Prak Eline T, Allman David
Abstract excerpt
Antibody secreting plasma cells are made in response to a variety of pathogenic and commensal microbes. While all plasma cells express a core gene transcription program that allows them to secrete large quantities of immunoglobulin, unique transcriptional profiles are linked to plasma cells expressing different antibody isotypes. IgA expressing plasma cells are generally thought of as short-lived in mucosal...
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