Back to search

Article

A microbiota-responsive polyfunctional cytotoxic CD4+ T-cell state promotes mucosal inflammation in ulcerative colitis

2026-08-14

Abstract excerpt

Ulcerative colitis (UC) is characterised by chronic colonic inflammation with marked heterogeneity in disease severity and therapeutic outcomes. Here, we define a spatially organised, polyfunctional cytotoxic CD4+ T-cell state associated with mucosal inflammation and adverse therapeutic outcomes in UC. Integrating ex vivo T-cell receptor stimulation with multi-cohort bulk and single-cell transcriptomics and multip...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
d3118ec3-25aa-5465-aeb0-df6fdfe18d2b
DOI
10.64898/2026.08.10.743953
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A microbiota-responsive polyfunctional cytotoxic CD4+ T-cell state promotes mucosal inflammation in ulcerative colitisDOI 10.64898/2026.08.10.743953
Tissue-embedded CD4⁺ plasticity defines mucosal immunity in Inflammatory Bowel DiseaseSemantic proximity
Pro-inflammatory innate-like T cells are expanded in the blood and inflamed intestine in Crohn’s DiseaseSemantic proximity
Ulcerative colitis immune cell landscapes and differentially expressed gene signatures determine novel regulators and predict clinical response to biologic therapySemantic proximity
Altered interactions between circulating and tissue-resident CD8 T cells with the colonic mucosa define colitis associated with immune checkpoint inhibitorsSemantic proximity
Integration of single-cell transcriptome and genetic profiles reveals critical cell types and genes in inflammatory bowel diseaseSemantic proximity
Myeloid cell influx into the colonic epithelium is associated with disease severity and non-response to anti-Tumor Necrosis Factor Therapy in patients with Ulcerative ColitisSemantic proximity
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colonSemantic proximity
The landscape of immune dysregulation in Crohn’s disease revealed through single-cell transcriptomic profiling in the ileum and colonSemantic proximity
A conserved population of MHC II-restricted, innate-like, commensal-reactive T cells in the gut of humans and miceSemantic proximity
Single cell transcriptional profiling reveals helper, effector, and regulatory MAIT cell populations enriched during homeostasis and activationSemantic proximity
Deciphering the immunocellular regulatory network in inflammatory bowel disease: from susceptibility genes to cellular effectors and toward precision therapies.Semantic proximity
Single-cell analysis of colonic epithelium reveals unexpected shifts in cellular composition and molecular phenotype in treatment-naïve adult Crohn’s diseaseSemantic proximity
Select a neighboring publication to make it the new centre.