Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Distinct systemic and gut IgA responses to bacteria of the human upper gastrointestinal tract

24 Jul 2026

Abstract excerpt

The mucosa lining the gastrointestinal tract harbors the body's largest population of plasma cells, most of which produce dimeric immunoglobulin A (IgA) for release into the lumen. In addition, there is systemic production of monomeric IgA circulating in the blood. Little is known about the connection between systemic and mucosal IgA. To address this relationship and to explore antibody responses against the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clostridium difficile and Clostridium perfringens research
Share to Escherichia coli research studies
Share to Gut microbiota and health

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 42497062
DOI: 10.1016/j.celrep.2026.117721

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Distinct systemic and gut IgA responses to bacteria of the human upper gastrointestinal tractPMID 42497062Read ↗

IgA deficiency destabilizes immunological homeostasis towards intestinal microbiota and increases the risk of systemic immune dysregulationSemantic proximity Read ↗

Innate and Adaptive Humoral Responses Coat Distinct Commensal Bacteria with Immunoglobulin A.Semantic proximity Read ↗

IgA Plasma Cells Are Long-Lived Residents of Gut and Bone Marrow That Express Isotype- and Tissue-Specific Gene Expression Patterns.Semantic proximity Read ↗

Natural polyreactive IgA antibodies coat the intestinal microbiotaSemantic proximity Read ↗

Immunoglobulin subtype-coated bacteria are correlated with the disease activity of inflammatory bowel diseaseSemantic proximity Read ↗

The systemic anti-microbiota IgG repertoire can identify gut bacteria that translocate across gut barrier surfacesSemantic proximity Read ↗

Human IgA binds a diverse array of commensal bacteriaSemantic proximity Read ↗

Dynamic immunoglobulin responses to gut bacteria during inflammatory bowel diseaseSemantic proximity Read ↗

Immunoglobulin A, an Active Liaison for Host-Microbiota HomeostasisSemantic proximity Read ↗

Communication between B-Cells and Microbiota for the Maintenance of Intestinal HomeostasisSemantic proximity Read ↗

Metagenomic Immunoglobulin Sequencing (MIG-Seq) Exposes Patterns of IgA Antibody Binding in the Healthy Human Gut MicrobiomeSemantic proximity Read ↗

High microbiota reactivity of adult human intestinal IgA requires somatic mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.