Article

Retrospective analysis of enhancer activity and transcriptome history

2021-09-08

Abstract excerpt

Cell state changes in development and disease are controlled by gene regulatory networks, the dynamics of which are difficult to track in real time. Here, we utilize an inducible DCM-RNA-polymerase-subunit-b fusion protein, to label active genes and enhancers with a bacterial methylation mark that does not affect gene transcription and is propagated in S-phase. We applied this DCM-time-machine (DCM-TM) technology...

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Literature Corpus work: da070da9-6107-5876-bb31-9b323f1a8846
DOI: 10.1101/2021.09.07.459233

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