Article

Human DCM-time machine unravels cell state changes during primitive gut tube differentiation

2025-09-26

Abstract excerpt

Cell state changes in development and differentiation are directed by gene and enhancer activity changes, the dynamics of which are difficult to study in real time. To be able to define lineage paths and monitor time resolved cell state changes during pluripotent stem cell differentiation, we introduced the DCM-time machine technology (DCM-TM) into human induced pluripotent stem cells (iPSCs). We demonstrate that,...

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Literature Corpus work: 70e346f1-6b3b-5375-811d-5db52182e948
DOI: 10.1101/2025.09.26.678757

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