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Article

Complement C3- and CR3-dependent microglial clearance protects photoreceptors in retinitis pigmentosa

2018-12-21

Abstract excerpt

Complement activation has been implicated as an inflammatory driver of neurodegeneration in retinal and brain pathologies. However, its involvement and influence of photoreceptor degeneration in retinitis pigmentosa (RP), an inherited, largely incurable blinding disease, is unclear. We discover that markedly upregulated retinal expression of multiple complement components coincided spatiotemporally with photorecep...

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Identifiers and source

Literature Corpus work
da02421f-4689-5bc2-bb89-ffe10306e55e
DOI
10.1101/504647
Open publication

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Complement C3- and CR3-dependent microglial clearance protects photoreceptors in retinitis pigmentosaDOI 10.1101/504647
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