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Article

Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy

3 May 2018

Abstract excerpt

Geographic atrophy (GA), the advanced form of dry age-related macular degeneration (AMD), is characterized by progressive loss of retinal pigment epithelium cells and photoreceptors in the setting of characteristic extracellular deposits and remains a serious unmet medical need. While genetic predisposition to AMD is dominated by polymorphisms in complement genes, it remains unclear how complement activation...

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Share to Complement system in diseases
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PMID: 29743491
DOI: 10.1038/s41598-018-25557-8

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