Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel role of complement in retinal degeneration.

Investigative ophthalmology & visual science - 19 Nov 2012

Yu Minzhong, Zou Weilin, Peachey Neal S, McIntyre Thomas M, Liu Jinbo

Abstract excerpt

PURPOSE: The association of single nucleotide polymorphisms of components of the complement alternative pathway with the risk of age-related macular degeneration (AMD) indicates that complement signaling plays an important role in retinal physiology. How genetic variation leads to retinal degeneration is unknown. It has been assumed that complement activation augments immune responses, which in turn initiate AMD...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Complement Activation
Share to Complement C3
Share to Complement C5

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electroretinography

Share to Immunohistochemistry

Share to Macular Degeneration

Share to Mass Spectrometry

Share to Retina

Source

Open in PubMed Open full text

Identifiers

PMID: 23074214
DOI: 10.1167/iovs.12-10069
PMCID: PMC4606790

Genes

ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel role of complement in retinal degeneration.PMID 23074214Read ↗

Intracellular complement C3/C3aR/STAT3 pathway inactivation attenuates retinal degeneration in miceSemantic proximity Read ↗

The complement system in age-related macular degeneration.Semantic proximity Read ↗

AMD and the alternative complement pathway: genetics and functional implications.Semantic proximity Read ↗

Implications of genetic variation in the complement system in age-related macular degeneration.Semantic proximity Read ↗

Complement, Age-Related Macular Degeneration and a Vision of the FutureSemantic proximity Read ↗

Complement regulation in the eye: implications for age-related macular degenerationSemantic proximity Read ↗

Complement system in pathogenesis of AMD: dual player in degeneration and protection of retinal tissue.Semantic proximity Read ↗

Complement System and Potential Therapeutics in Age-Related Macular DegenerationSemantic proximity Read ↗

The role of complement in ocular pathologySemantic proximity Read ↗

The complement system in age-related macular degeneration: A review of rare genetic variants and implications for personalized treatment.Semantic proximity Read ↗

Complement Component C3 Plays a Critical Role in Protecting the Aging Retina in a Murine Model of Age-Related Macular DegenerationSemantic proximity Read ↗

Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.