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Article

Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Jun 2014

Peng Bo, Xiao Jia, Wang Ke, So Kwok-Fai, Tipoe George L, Lin Bin

Abstract excerpt

Retinitis pigmentosa (RP) is a photoreceptor-degenerative disease caused by various mutations and is characterized by death of rod photoreceptor cell followed by gradual death of cone photoreceptors. The molecular mechanisms that lead to rod and cone death are not yet fully understood. Neuroinflammation contributes to the progression of many chronic neurodegenerative disorders. However, it remains to be...

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Identifiers

PMID: 24920619
DOI: 10.1523/JNEUROSCI.5200-13.2014
PMCID: PMC6608244

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