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Article

Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina

1 Nov 2019

Abstract excerpt

Complement dysregulation is a feature of many retinal diseases, yet mechanistic understanding at the cellular level is limited. Given this knowledge gap about which retinal cells express complement, we performed single-cell RNA sequencing on ∼92,000 mouse retinal cells and validated our results in five major purified retinal cell types. We found evidence for a distributed cell-type-specific complement expression...

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PMID: 31775049
DOI: 10.1016/j.celrep.2019.10.084

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