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Article

Intracellular complement C3/C3aR/STAT3 pathway inactivation attenuates retinal degeneration in mice

2020-12-22

Abstract excerpt

<title>Abstract</title> <p>Background Age-related macular degeneration (AMD) threatens vision in elderly people globally. Systemic complement C3 has been shown to be tightly associated with AMD. However, the mechanism of how local retinal complement C3 and downstream pathway mediated retinal degeneration is not entirely clear. Methods Wild-type, C3 knockout mice and mice treated with a C3aR inhibitor (SB290157)...

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Literature Corpus work
616b5634-fb93-551a-9af8-78de11fd3bd3
DOI
10.21203/rs.3.rs-131692/v1
Open publication

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Intracellular complement C3/C3aR/STAT3 pathway inactivation attenuates retinal degeneration in miceDOI 10.21203/rs.3.rs-131692/v1
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