Article

Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency

2024-06-24

Abstract excerpt

Selective IgA deficiency (SIgAD) is the most common inborn error of immunity (IEI). Unlike many IEIs, evidence of a role for highly penetrant rare variants in SIgAD is lacking. Known SIgAD-associated variants are common in the general population, but previous studies have had limited power to identify common-variant associations due to their small sample size. We sought to overcome this problem first through meta-...

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Literature Corpus work: d9fdf2bf-20a9-5fd2-ba42-0d4c75927c1f
DOI: 10.1101/2024.06.24.24309378

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