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Article

Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.

Nature genetics - 1 Sept 2010

Ferreira Ricardo C, Pan-Hammarström Qiang, Graham Robert R, Gateva Vesela, Fontán Gumersindo, Lee Annette T, Ortmann Ward, Urcelay Elena, Fernández-Arquero Miguel, Núñez Concepción, Jorgensen Gudmundur, Ludviksson Björn R, Koskinen Sinikka, Haimila Katri, Clark Hilary F, Klareskog Lars, Gregersen Peter K, Behrens Timothy W, Hammarström Lennart

Abstract excerpt

To understand the genetic predisposition to selective immunoglobulin A deficiency (IgAD), we performed a genome-wide association study in 430 affected individuals (cases) from Sweden and Iceland and 1,090 ethnically matched controls, and we performed replication studies in two independent European cohorts. In addition to the known association of HLA with IgAD, we identified association with a nonsynonymous...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20694011
DOI: 10.1038/ng.644

Genes

IFIH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency.PMID 20694011Read ↗

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Brief Report: IFIH1 Mutation Causes Systemic Lupus Erythematosus With Selective IgA DeficiencySemantic proximity Read ↗

Fine-scale mapping at IGAD1 and genome-wide genetic linkage analysis implicate HLA-DQ/DR as a major susceptibility locus in selective IgA deficiency and common variable immunodeficiency.Semantic proximity Read ↗

Leveraging pleiotropy identifies common-variant associations with selective IgA deficiencySemantic proximity Read ↗

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