Article
Leveraging pleiotropy identifies common-variant associations with selective IgA deficiency.
Clinical immunology (Orlando, Fla.) - 1 Nov 2024
Willis Thomas W, Gkrania-Klotsas Effrossyni, Wareham Nicholas J, McKinney Eoin F, Lyons Paul A, Smith Kenneth G C, Wallace Chris
Abstract excerpt
Selective IgA deficiency (SIgAD) is the most common inborn error of immunity (IEI). Unlike many IEIs, evidence of a role for highly penetrant rare variants in SIgAD is lacking. Previous SIgAD studies have had limited power to identify common variants due to their small sample size. We overcame this problem first through meta-analysis of two existing GWAS. This identified four novel common-variant associations and...
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