Article
Genetic sharing and heritability of paediatric age of onset autoimmune diseases.
Nature communications - 9 Oct 2015
Li Yun R, Zhao Sihai D, Li Jin, Bradfield Jonathan P, Mohebnasab Maede, Steel Laura, Kobie Julie, Abrams Debra J, Mentch Frank D, Glessner Joseph T, Guo Yiran, Wei Zhi, Connolly John J, Cardinale Christopher J, Bakay Marina, Li Dong, Maggadottir S Melkorka, Thomas Kelly A, Qui Haijun, Chiavacci Rosetta M, Kim Cecilia E, Wang Fengxiang, Snyder James, Flatø Berit, Førre Øystein, Denson Lee A, Thompson Susan D, Becker Mara L, Guthery Stephen L, Latiano Anna, Perez Elena, Resnick Elena, Strisciuglio Caterina, Staiano Annamaria, Miele Erasmo, Silverberg Mark S, Lie Benedicte A, Punaro Marilynn, Russell Richard K, Wilson David C, Dubinsky Marla C, Monos Dimitri S, Annese Vito, Munro Jane E, Wise Carol, Chapel Helen, Cunningham-Rundles Charlotte, Orange Jordan S, Behrens Edward M, Sullivan Kathleen E, Kugathasan Subra, Griffiths Anne M, Satsangi Jack, Grant Struan F A, Sleiman Patrick M A, Finkel Terri H, Polychronakos Constantin, Baldassano Robert N, Luning Prak Eline T, Ellis Justine A, Li Hongzhe, Keating Brendan J, Hakonarson Hakon
Abstract excerpt
Autoimmune diseases (AIDs) are polygenic diseases affecting 7-10% of the population in the Western Hemisphere with few effective therapies. Here, we quantify the heritability of paediatric AIDs (pAIDs), including JIA, SLE, CEL, T1D, UC, CD, PS, SPA and CVID, attributable to common genomic variations (SNP-h(2)). SNP-h(2) estimates are most significant for T1D (0.863±s.e. 0.07) and JIA (0.727±s.e. 0.037), more...
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