Article
Genetic regulation of serum IgA levels and susceptibility to common immune, infectious, kidney, and cardio-metabolic traits.
Nature communications - 11 Nov 2022
Liu Lili, Khan Atlas, Sanchez-Rodriguez Elena, Zanoni Francesca, Li Yifu, Steers Nicholas, Balderes Olivia, Zhang Junying, Krithivasan Priya, LeDesma Robert A, Fischman Clara, Hebbring Scott J, Harley John B, Moncrieffe Halima, Kottyan Leah C, Namjou-Khales Bahram, Walunas Theresa L, Knevel Rachel, Raychaudhuri Soumya, Karlson Elizabeth W, Denny Joshua C, Stanaway Ian B, Crosslin David, Rauen Thomas, Floege Jürgen, Eitner Frank, Moldoveanu Zina, Reily Colin, Knoppova Barbora, Hall Stacy, Sheff Justin T, Julian Bruce A, Wyatt Robert J, Suzuki Hitoshi, Xie Jingyuan, Chen Nan, Zhou Xujie, Zhang Hong, Hammarström Lennart, Viktorin Alexander, Magnusson Patrik K E, Shang Ning, Hripcsak George, Weng Chunhua, Rundek Tatjana, Elkind Mitchell S V, Oelsner Elizabeth C, Barr R Graham, Ionita-Laza Iuliana, Novak Jan, Gharavi Ali G, Kiryluk Krzysztof
Abstract excerpt
Immunoglobulin A (IgA) mediates mucosal responses to food antigens and the intestinal microbiome and is involved in susceptibility to mucosal pathogens, celiac disease, inflammatory bowel disease, and IgA nephropathy. We performed a genome-wide association study of serum IgA levels in 41,263 individuals of diverse ancestries and identified 20 genome-wide significant loci, including 9 known and 11 novel loci....
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