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Shared genetic study gives insights into the shared and distinct pathogenic immunity components of IgA nephropathy and SLE.

Molecular genetics and genomics : MGG - 1 Jul 2021

Zhang Yue-Miao, Zhou Xu-Jie, Wang Yan-Na, Liu Xing-Zi, Wang Yong-Fei, Lau Yu-Lung, Yang Wan-Ling, Zhang Hong

Abstract excerpt

An autoimmune component has been suggested to play a role in pathogenesis of IgA nephropathy (IgAN). And genetic studies have reported the shared susceptibility loci between IgAN and the prototype autoimmune disease systemic lupus erythematosus (SLE). This study was designed to systemically identify and annotate the shared susceptibility genes between IgAN and SLE. We first conducted an imputation-based...

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PMID: 34076728
DOI: 10.1007/s00438-021-01798-7

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