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Article

Novel genes and variants associated with IgA nephropathy by co-segregating with the disease phenotypes in 10 IgAN families.

Gene - 15 Oct 2015

Liu Ruihong, Hu Bin, Li Qibin, Jing Xiangyi, Zhong Cheng, Chang Yu, Liao Qijun, Lam Man F, Leung Joseph C K, Lai Kar N, Wang Yiming

Abstract excerpt

BACKGROUND: Previously, a large proportion of the genetic components predisposing individuals to IgA nephropathy (IgAN) have been unidentified. Familial IgAN is enriched with genetic variations predisposing individuals to the disease. Whole exome sequencing is an effective way to explore disease-causing genes and gene variants. METHODS: We performed exome sequencing on the probands from each of ten IgAN families,...

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Source

Identifiers

PMID: 26095808
DOI: 10.1016/j.gene.2015.06.041

Genes

DEFA4
CARD8
MYCT1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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