Article
High-density SNP mapping of the HLA region identifies multiple independent susceptibility loci associated with selective IgA deficiency.
PLoS genetics - 1 Jan 2012
Ferreira Ricardo C, Pan-Hammarström Qiang, Graham Robert R, Fontán Gumersindo, Lee Annette T, Ortmann Ward, Wang Ning, Urcelay Elena, Fernández-Arquero Miguel, Núñez Concepción, Jorgensen Gudmundur, Ludviksson Björn R, Koskinen Sinikka, Haimila Katri, Padyukov Leonid, Gregersen Peter K, Hammarström Lennart, Behrens Timothy W
Abstract excerpt
Selective IgA deficiency (IgAD; serum IgA<0.07 g/l) is the most common form of human primary immune deficiency, affecting approximately 1∶600 individuals in populations of Northern European ancestry. The polygenic nature of IgAD is underscored by the recent identification of several new risk genes in a genome-wide association study. Among the characterized susceptibility loci, the association with specific HLA...
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