Article

CD8+ T-cell-mediated immunoediting influences genomic evolution and immune evasion in murine gliomas

2019-07-16

Abstract excerpt

Cancer immunoediting shapes tumor progression by the selection of tumor cell variants that can evade immune recognition. Given the immune evasion and intra-tumor heterogeneity intrinsic to gliomas, we hypothesized that CD8+ T-cells mediate immunoediting in these tumors. We evaluated glioma progression in the absence of CD8+ T-cells by depleting this immune cell population in transgenic murine gliomas. Upon transpl...

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Literature Corpus work: 1eb5ab3b-19d3-56e2-b683-5ef0d0977d08
DOI: 10.1101/705152

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