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Article

Functional profiling of murine glioma models highlights targetable immune evasion phenotypes.

Acta neuropathologica - 27 Nov 2024

Mikolajewicz Nicholas, Tatari Nazanin, Wei Jiarun, Savage Neil, Granda Farias Adrian, Dimitrov Vassil, Chen David, Zador Zsolt, Dasgupta Kuheli, Aguilera-Uribe Magali, Xiao Yu-Xi, Lee Seon Yong, Mero Patricia, McKenna Dillon, Venugopal Chitra, Brown Kevin R, Han Hong, Singh Sheila, Moffat Jason

Abstract excerpt

Cancer-intrinsic immune evasion mechanisms and pleiotropy are a barrier to cancer immunotherapy. This is apparent in certain highly fatal cancers, including high-grade gliomas and glioblastomas (GBM). In this study, we evaluated two murine syngeneic glioma models (GL261 and CT2A) as preclinical models for human GBM using functional genetic screens, single-cell transcriptomics and machine learning approaches....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39592459
DOI: 10.1007/s00401-024-02831-w
PMCID: PMC11599368

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