BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAFV600E-mutant glioma.

doi:10.1016/j.xcrm.2025.102183

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Article

BRAF/MEK inhibition induces cell state transitions boosting immune checkpoint sensitivity in BRAFV600E-mutant glioma.

Cell reports. Medicine - 17 Jun 2025

Xing Yao Lulu, Panovska Dena, Park Jong-Whi, Grossauer Stefan, Koeck Katharina, Bui Brandon, Nasajpour Emon, Nirschl Jeffrey J, Feng Zhi-Ping, Cheung Pierre, Habib Pardes, Wei Ruolun, Wang Jie, Thomason Wes, Monje Michelle, Xiu Joanne, Beck Alexander, Weber Katharina J, Harter Patrick N, Lim Michael, Mahaney Kelly B, Prolo Laura M, Grant Gerald A, Ji Xuhuai, Walsh Kyle M, Mulcahy Levy Jean M, Hambardzumyan Dolores, Petritsch Claudia K

Abstract excerpt

Resistance to v-raf murine sarcoma viral oncogene homolog B1 (BRAF) plus mitogen-activated protein kinase kinase (MEK) inhibition (BRAFi+MEKi) in BRAFV600E-mutant gliomas drives rebound, progression, and high mortality, yet it remains poorly understood. This study addresses the urgent need to develop treatments for BRAFi+MEKi-resistant glioma using preclinical mouse models and patient-derived materials....

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Identifiers

PMID: 40505659
DOI: 10.1016/j.xcrm.2025.102183
PMCID: PMC12208339

Genes

BRAF

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