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Rewiring of 3D Enhancer-Promoter Interactome Underlies Diabetic Endothelial Dysfunction

2026-03-05

Abstract excerpt

<h4>Background</h4> Diabetic vascular complications are driven by endothelial dysfunction, yet the role of 3D genome organization in this process is unknown. We sought to define the alterations in chromatin architecture in diabetic endothelium and identify the key regulators involved. <h4>Methods</h4> We generated a high-resolution 3D epigenomic atlas of diabetic endothelial cells from mouse models and human sub...

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Literature Corpus work
d9f6354e-592c-55fd-ba41-067326314f28
DOI
10.64898/2026.03.03.709273
Open publication

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Rewiring of 3D Enhancer-Promoter Interactome Underlies Diabetic Endothelial DysfunctionDOI 10.64898/2026.03.03.709273
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