Article

Dynamic changes in RNA-chromatin interactome promote endothelial dysfunction

2019-07-24

Abstract excerpt

Chromatins are pervasively attached by RNAs. Here, we asked whether global RNA-chromatin contacts are altered in a given cell type in a disease context, and whether these alterations impact gene expression and cell function. In endothelial cells (ECs) treated by high-glucose and TNFα, we employed single-cell RNA-sequencing and in situ mapping of RNA-genome interaction (iMARGI) assay to delineate temporal changes...

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Literature Corpus work: 754440ec-1523-55c3-a4f3-d229f73eb39b
DOI: 10.1101/712950

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