Article
Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells.
Genome research - 1 Oct 2011
Pirola Luciano, Balcerczyk Aneta, Tothill Richard W, Haviv Izhak, Kaspi Antony, Lunke Sebastian, Ziemann Mark, Karagiannis Tom, Tonna Stephen, Kowalczyk Adam, Beresford-Smith Bryan, Macintyre Geoff, Kelong Ma, Hongyu Zhang, Zhu Jingde, El-Osta Assam
Abstract excerpt
Emerging evidence suggests that poor glycemic control mediates post-translational modifications to the H3 histone tail. We are only beginning to understand the dynamic role of some of the diverse epigenetic changes mediated by hyperglycemia at single loci, yet elevated glucose levels are thought to regulate genome-wide changes, and this still remains poorly understood. In this article we describe genome-wide...
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