Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Endothelial cells (ECs) make up the innermost layer throughout the entire vasculature. Their phenotypes and physiological functions are initially regulated by developmental signals and extracellular stimuli. The underlying molecular mechanisms responsible for the diverse phenotypes of ECs from different organs are not well understood. <h4>Results</h4> To characterize the tr...

Topics

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• Endothelial Cells
• Enhancer Elements, Genetic
• Genome-Wide Association Study
• Neovascularization, Pathologic
• Polymorphism, Single Nucleotide
• Regulatory Sequences, Nucleic Acid
• Transcription Factor AP-1
• Vascular Endothelial Growth Factor A

Identifiers and source

Literature Corpus work

426eca53-5238-5018-bf2a-8882263545b3

DOI

10.1101/756056