Article

Targeting the Histone Methyltransferase SETD7 Rescues Diabetes-induced Impairment of Angiogenic Response by Transcriptional Repression of Semaphorin 3G

2023-12-06

Abstract excerpt

<h4>Background</h4> Peripheral artery disease (PAD) is highly prevalent in patients with diabetes (DM) and associates with a poor prognosis. Revascularization strategies failed to improve outcome, suggesting that new strategies to promote blood vessel growth are needed. Histone modifications have emerged as key modulators of gene expression, however their role in angiogenic response in DM remains poorly understood...

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Literature Corpus work: cb045d3d-5554-5dfe-a62a-b894550f51b6
DOI: 10.1101/2023.12.05.23299540

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