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Engrafted parenchymal brain macrophages differ from microglia in transcriptome, chromatin landscape and response to challenge

30 Nov 2018

Abstract excerpt

Microglia are yolk sac-derived macrophages residing in the parenchyma of brain and spinal cord, where they interact with neurons and other glial. After different conditioning paradigms and bone marrow (BM) or hematopoietic stem cell (HSC) transplantation, graft-derived cells seed the brain and persistently contribute to the parenchymal brain macrophage compartment. Here we establish that graft-derived macrophages...

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PMID: 30523248
DOI: 10.1038/s41467-018-07548-5

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