Article

Engrafted parenchymal brain macrophages differ from host microglia in transcriptome, epigenome and response to challenge

2018-07-16

Abstract excerpt

Microglia are yolk sac-derived macrophages residing in the parenchyma of brain and spinal cord, where they interact with neurons and other glial cells by constantly probing their surroundings with dynamic extensions. Following different conditioning paradigms and bone marrow (BM) / hematopoietic stem cell (HSC) transplantation, graft-derived cells seed the brain and persistently contribute to the parenchymal brain...

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Literature Corpus work: c2a2b31f-d110-5cd8-aa1a-75b680eaf26a
DOI: 10.1101/369942

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