Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease.

doi:10.1016/j.immuni.2025.03.019

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Article

Direct microglia replacement reveals pathologic and therapeutic contributions of brain macrophages to a monogenic neurological disease.

Immunity - 13 May 2025

Aisenberg William H, O'Brien Carleigh A, Sangster Madison, Yaqoob Fazeela, Zhang Yuanchao, Temsamrit Brian, Thom Searlait, Gosse Luca, Chaluvadi Sai, Elfayomi Bilal, Lee Gavin, Polam Vidhur, Levitt Eli M, Liu Gary, Lombroso Sonia I, Nemec Kelsey M, Clowry Gavin, Nieves Cassaundra, Rawat Priyanka, Church Emily, Martinez Daniel, Shoffler Clarissa, Kancheva Daliya, Petucci Christopher, Taylor Deanne, Kofler Julia, Erskine Daniel, Movahedi Kiavash, Bennett Mariko L, Bennett F Chris

Abstract excerpt

Krabbe disease, also named globoid cell (GC) leukodystrophy (GLD) for its distinct lipid-laden macrophages, is a severe leukodystrophy caused by galactosylceramidase (GALC) mutations. Hematopoietic stem cell transplant (HSCT) ameliorates disease and is associated with central nervous system (CNS) engraftment of GALC+ donor macrophages. Yet, the role of macrophages in GLD pathophysiology and HSCT remains unclear....

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Identifiers

PMID: 40311614
DOI: 10.1016/j.immuni.2025.03.019
PMCID: PMC12078009

Genes

GALC
GC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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