Article

Integrative single-cell analysis of neural stem/progenitor cells reveals epigenetically dysregulated interferon response in progressive multiple sclerosis

2024-02-09

Abstract excerpt

<h4>SUMMARY</h4> Progressive multiple sclerosis (PMS) is characterized by a primary smouldering pathological disease process associated with a superimposed inflammatory activity. Cellular and molecular processes sustaining the pathobiology of PMS remain to be identified. We previously discovered senescence signatures in neural stem/progenitor cells (NSCs) from people with PMS. Applying direct reprogramming to gen...

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Literature Corpus work: d99a84e7-83f4-54e5-ab12-a6cd8e154bdc
DOI: 10.1101/2024.02.09.579648

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