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Article

Stat1 is an inducible transcriptional repressor of neural stem cells self-renewal program during neuroinflammation

16 Aug 2023

Abstract excerpt

A central issue in regenerative medicine is understanding the mechanisms that regulate the self-renewal of endogenous stem cells in response to injury and disease. Interferons increase hematopoietic stem cells during infection by activating STAT1, but the mechanisms by which STAT1 regulates intrinsic programs in neural stem cells (NSCs) during neuroinflammation is less known. Here we explored the role of STAT1 on...

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PMID: 37663126
DOI: 10.3389/fncel.2023.1156802

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