Article

Increased Cholesterol Synthesis Drives Neurotoxicity in Patient Stem Cell-Derived Model of Multiple Sclerosis

2024-01-16

Abstract excerpt

<h4>SUMMARY</h4> Senescent neural progenitor cells have been identified in brain lesions of people with progressive multiple sclerosis (PMS). However, their role in disease pathobiology and contribution to the lesion environment remains unclear. By establishing directly induced neural stem/progenitor cell (iNSC) lines from PMS patient fibroblasts, we studied their senescent phenotype in vitro . Senescence was st...

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Literature Corpus work: 01e62d06-a4e3-5b31-b701-c7283ab8d6cb
DOI: 10.1101/2024.01.16.575826

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