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Article

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis.

Cell stem cell - 7 Nov 2024

Clayton Benjamin L L, Barbar Lilianne, Sapar Maria, Kalpana Kriti, Rao Chandrika, Migliori Bianca, Rusielewicz Tomasz, Paull Daniel, Brenner Katie, Moroziewicz Dorota, Sand Ilana Katz, Casaccia Patrizia, Tesar Paul J, Fossati Valentina

Abstract excerpt

Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS), resulting in neurological disability that worsens over time. While progress has been made in defining the immune system's role in MS pathophysiology, the contribution of intrinsic CNS cell dysfunction remains unclear. Here, we generated a collection of induced pluripotent stem cell (iPSC) lines from...

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Identifiers

PMID: 39191254
DOI: 10.1016/j.stem.2024.08.002
PMCID: PMC11560525

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