Article

Cerebral Organoids In Primary Progressive Multiple Sclerosis Reveal Stem Cell Disruption And Failure To Produce Oligodendrocytes

2022-06-26

Abstract excerpt

<h4>ABSTRACT</h4> Multiple sclerosis (MS) is an auto-immune inflammatory disorder affecting the central nervous system. The cause of the disease is unknown but both genetic and environmental factors are implicated in the pathogenesis. We derived cerebral organoids from induced pluripotent stem cells (iPSC) of healthy control subjects as well as from primary progressive MS (PPMS), secondary progressive MS (SPMS) a...

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Literature Corpus work: 17184567-e9b8-57c9-afbf-12eec54c7a1f
DOI: 10.1101/2022.06.24.497517

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