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Cellular senescence in progenitor cells contributes to diminished remyelination potential in progressive multiple sclerosis

25 Mar 2019

Abstract excerpt

Cellular senescence is a form of adaptive cellular physiology associated with aging. Cellular senescence causes a proinflammatory cellular phenotype that impairs tissue regeneration, has been linked to stress, and is implicated in several human neurodegenerative diseases. We had previously determined that neural progenitor cells (NPCs) derived from induced pluripotent stem cell (iPSC) lines from patients with...

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PMID: 30910981
DOI: 10.1073/pnas.1818348116

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